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-synuclein, that's a major element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which can be an E3 ubiquitin ligase and causes endoplasmic reticulum (ER) pressure, propose that dysfunction on the intracellular proteinase programs, like ubiquitin-proteasome procedure or lysosomal procedure, which gets rid of unnecessary poisonou

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